Antibody response to intravenous immunization following splenic tissue autotransplantation in Sprague-Dawley rats.
نویسندگان
چکیده
The response to intravenous challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity, or a surgically created omental pouch. There was a marked rise in heterophil antibody titer following intravenous challenge in ten control animals, and no rise in titer in nine of ten asplenic animals. Heterophil antibody titers increased in all of the animals with transplants, but the response in some was less than that in control animals. Thus autotransplanted splenic tissue demonstrated immunologic responses similar to those of normal, intact spleen.
منابع مشابه
Heterotropic splenic autotransplantation in the prevention of Haemophilus influenza meningitis and fatal sepsis in Sprague-Dawley rats.
It has been suggested that autotransplantation of splenic tissue following trauma may result in splenic implanta that protect the human host from severe infection with encapsulated bacteria. To test this hypothesis, Sprague-Dawley rats underwent sham operation, splenectomy, or splenectomy followed by autotransplantation of splenic fragments into the peritoneal cavity. Three months later, they w...
متن کاملHeterotopic Splenic Autotranspiantation in the Prevention of Haemophilus influenzae Meningitis and Fatal Sepsis in Sprague-Dawley Rats
It has been suggested that autotransplantation of splenic tissue following trauma may result in splenic implants that protect the human host from severe infection with encapsulated bacteria. To test this hypothesis. Sprague-Dawley rats underwent sham operation. splenectomy. or splenectomy followed by autotransplantation of splenic fragments into the peritoneal cavity. Three months later. they w...
متن کاملارزیابی تغییرات سلولی بافت طحال و تغییرات سرولوژیک خون محیطی در اتوترانسپلنتیشن طحال در مقایسه با موارد اسپلنکتومی شده در رت
Background & Aims: Spleen is one of the most common sites of injury after trauma. When splenectomy due to spleen damage is unavoidable, autotransplantation of splenic tissue is the only possible option to preserve splenic function. Immunologic function of spleen against infections is unremarkable but compensation levels of immunological activity and structural rearrangement of transplanted spl...
متن کاملSpleen autotransplantation provides restoration of functional splenic lymphoid compartments and improves the humoral immune response to pneumococcal polysaccharide vaccine.
After splenectomy, patients have an increased risk of overwhelming post-splenectomy infection (OPSI) or sepsis involving encapsulated bacteria such as pneumococcus. The value of spleen autotransplantation after splenectomy because of trauma has long been questioned. Much attention has been given to the restoration of mononuclear phagocyte system (MPS) function, which appeared to be similar to t...
متن کاملLack of protective effect of autotransplanted splenic tissue to pneumococcal challenge.
Studies in animals and clinical experience in patients have demonstrated that splenectomy may lead to an increased susceptibility to infection. The infections are usually caused by encapsulated bacteria such as penumococcus. It has been shown in a variety of experimental animals that autotransplanted splenic tissue is capable of regenerating into implants that are microscopically indistinguisha...
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عنوان ژورنال:
- Blood
دوره 49 5 شماره
صفحات -
تاریخ انتشار 1977